Bio

Tyler Gregory is a Biomedical Engineering Ph.D. candidate with anticipated graduation in 2025. His research optimizes bioink formulations for 3D bioprinting of tumor models by tuning hydrogel mechanics and cell dynamics, advancing realistic tissue mimics for improved anticancer drug screening and biofabrication techniques.

Research

Tyler Gregory’s research explores the effects of cell seeding densities and alginate composition on the viscoelastic properties of alginate-gelatin hydrogels, focusing on spheroid growth, cell viability, and bioink printability. By varying the molecular weight of alginate and seeding breast cancer cell lines at different densities, he conducts bulk rheological tests to determine how these factors influence the hydrogels’ mechanical behavior. His findings show that increased cell seeding densities reduce the hydrogel stiffness, allowing for lower extrusion pressures, which in turn decreases shear forces on the cells, enhancing their initial viability post-printing. This work aims to advance the biofabrication of tissue models that closely mimic the tumor microenvironment for more effective high-throughput anticancer drug screening.

Recent Publications:
https://doi.org/10.1016/j.jmbbm.2022.105474